The county of 10 million people was one of several that moved into the state’s orange tier, which is the second-least restrictive of California’s four-tier system.,The International Olympic Committee and International Paralympic Committee said they fully respect and accept the move

Placer County is one of 13 California counties that have moved Sunday to the red tier of California’s COVID-19 reopening framework, loosening some restrictions.,The counties became eligible to move from the purple tier (“widespread”) to the red tier (“substantial” spread) after the state hit its goal Friday of delivering 2 million COVID-19 doses to communities hit hardest by the pandemic, triggering new thresholds.,Butte County has qualified to move from the most stringent purple tier to the less-restrictive red tier of the state’s COVID-19 reopening plan.,For a county to move down to the red tier, there should be a case rate of 4-7 per 100,000 residents with a 5-8% test positivity rate. read more

By Jeffrey Heller | Reuters

JERUSALEM – Israeli Prime Minister Benjamin Netanyahu on Monday acknowledged differences with U.S. President Joe Biden over Iranian and Palestinian issues, but said they enjoy a “very strong” working relationship.,The White House on Friday denied that Biden was snubbing Netanyahu by failing to include him so far in an early round of phone calls to foreign leaders since taking office on Jan. 20.,Netanyahu dismissed any notion that Biden was intentionally excluding him, telling Israel’s Channel 12 television channel: “He’ll call … We have had very strong friendly relations for nearly 40 years, dating from the time I came to Washington as an Israeli diplomatic representative and he was a young senator from Delaware.”,Netanyahu may find the alliance tested if Washington restores U.S. participation in the Iran nuclear deal, from which Trump withdrew, and opposes Israeli settlement building on occupied land where Palestinians seek statehood.,On Friday, the White House said Biden and Netanyahu would speak soon, but gave no date. read more

By PAUL J. WEBER and JAKE BLEIBERG

AUSTIN, Texas (AP) — A sprawling blast of winter weather across the U.S. is likely to blame for the deaths of two people in Texas, where an unusually snowy emergency Monday knocked out power for more than four million people, shut down grocery stores and air travel and closed schools ahead of frigid days still to come.,As nightfall threatened to plummet temperatures again into single digits, officials warned that homes still without power would likely not have heat until at least Tuesday, as frustration mounted and the state’s electric grid came under growing demand and criticism.,Massive power outages across Houston included a facility storing 8,000 doses of Moderna vaccine, leaving health officials scrambling to find takers at the same time authorities were pleading for people to stay home.,Temperatures nosedived into the single-digits as far south as San Antonio, and homes that had already been without electricity for hours had no certainty about when the lights and heat would come back on, as the state’s overwhelmed power grid began imposing blackouts that are typically only seen in 100-degree Fahrenheit (38-degree Celsius) summers.,State officials said surging demand, driven by people trying to keep their homes warm, and cold weather knocking some power stations offline had pushed Texas’ system beyond the limits. read more

President Joe Biden has responded by including a provision in the massive pandemic relief bill that would more than double the minimum wage from the current $7.25 to $15 per hour.,The Senate’s parliamentarian may further complicate things with a ruling that the minimum wage measure can’t be included in the pandemic bill.,For now, the measure’s most progressive Senate backers aren’t openly pressuring Biden to step up his campaign for a higher minimum wage.,The Rev. Dr. William J. Barber II, the co-chair of the Poor People’s Campaign, said Biden has a “mandate” to ensure the minimum wage increases, noting that minority Americans were “the first to go back to jobs, first to get infected, first to get sick, first to die” during the pandemic.,Biden suggested in the same interview that he’s prepared to engage in a “separate negotiation” on raising the minimum wage, but White House press secretary Jen Psaki offered no further details on the future of the proposal if it is in fact cut from the final coronavirus aid bill.

A paper published in the journal Nature Communications, reveals a potential revolutionary drug combination that -- in animal studies and in world-first 3D models of the tumour -- is "spectacularly effective in eradicating the cancer cells," according to lead researcher and paediatric oncologist Associate Professor c from the Children's Cancer Institute and Sydney Children's Hospital.,These models have been used to show that DIPG can bypass the activity of DFMO by pumping polyamines into cancer, essentially allowing the tumour to continue growing despite treatment with DFMO.,They have now made the breakthrough discovery that treatment with a new developmental drug, AMXT 1501, potently blocks the transport of polyamines into the DIPG cancer cell.,Treatment with AMXT 1501 was found to re-sensitize the DIPG cells to DFMO leading to what Associate Professor Ziegler said, "was a spectacular response in animal models, with a significantly increased survival and minimal toxicity (side effects).",Associate Professor Ziegler said that clinical trials of the drug combination in DIPG are planned to begin this year in children in a global study led by the Children's Cancer Institute and the Kid's Cancer Centre at Sydney Children's Hospital.

Futures Inc., which has been in business for 30 years, has had a location in West Hartford for 16 years, but recently has become much more physically visible in the community.,In West Hartford, The Kitchen at Futures Inc. operates a teaching kitchen that shares space with the offices on South Quaker Lane, and in August 2020, they opened the organization’s third brick and mortar retail location, Good Cause Gifts, which shares space with Nutmeg State Financial Credit Union at 973 Farmington Ave.

Good Cause Gifts also has stores in Berlin and at the Hospital for Special Care in New Britain – and the Kitchen at Futures Inc. also runs the cafe at the hospital.,“One of our biggest goals to opening a store in West Hartford Center was to get our name into the community and share what Futures Inc. and Good Cause Gifts is doing – while also providing another great shopping option for our town,” said DonAroma.,“In addition to shifting to a stronger online presence, simultaneous to opening our West Hartford Good Cause Gifts location, we also built an online store (goodcausegifts.org).,One of the key goals for opening the West Hartford Center store and launching the online store was working with more local vendors and businesses, and Futures Inc. has succeeded on that front as well. read more

WASHINGTON (AP) — The Latest on former President Donald Trump’s second Senate impeachment trial (all times local):

11:00 p.m. read more

Leonard was sidelined with a left lower leg contusion; Paul George missed his fifth consecutive game with what’s being classified as bone edema in a right toe.,Clippers coach Tyronn Lue said he didn’t know when Leonard’s injury occurred of what his prognosis was — or what George’s is either, for that matter.,“I’m not sure, but it happened on this road trip,” Lue said of Leonard’s contusion, noting that he just learned he’d miss the game Sunday.,And in the past four games with out George, Leonard has increased his offensive output, averaging 29.3 points, shooting 51.2% from the field.,The Clippers are 1-1 so far when they’ve had to play without both Leonard and George — who currently rank third and fifth among Western Conference vote-getters in fan voting for the All-Star Game.

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LOS ANGELES — The rates of new coronavirus infections and hospitalizations continue to fall across California, but the state’s death toll remains persistently high.,___ read more

A paper published today 12 Feb 2021 in the prestigious journal, Nature Communications, reveals a potential revolutionary drug combination that - in animal studies and in world-first 3D models of the tumor - is "spectacularly effective in eradicating the cancer cells," according to lead researcher and pediatric oncologist Associate Professor David Ziegler, from the Children's Cancer Institute and Sydney Children's Hospital.,These models have been used to show that DIPG can bypass the activity of DFMO by pumping polyamines into cancer, essentially allowing the tumor to continue growing despite treatment with DFMO.,They have now made the breakthrough discovery that treatment with a new developmental drug, AMXT 1501, potently blocks the transport of polyamines into the DIPG cancer cell.,Treatment with AMXT 1501 was found to re-sensitize the DIPG cells to DFMO leading to what Associate Professor Ziegler said, "was a spectacular response in animal models, with a significantly increased survival and minimal toxicity (side effects)".,Associate Professor Ziegler said that clinical trials of the drug combination in DIPG are planned to begin this year in children in a global study led by the Children's Cancer Institute and the Kid's Cancer Centre at Sydney Children's Hospital.